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Androgen excess disorders: fast facts
- Androgen-related disorders affect 6-8% of women of reproductive age, affecting 3.7 - 4.9 million in the US, and 89 - 119 million women worldwide.
- 70-90% of androgen excess is due to polycystic ovary syndrome (PCOS) with non-classic (late onset) adrenal hyperplasia, androgen secreting tumors, and syndromes of severe insulin resistance affecting the remainder.
- Idiopathic hirsutism, although not strictly a disorder of androgen excess, affects approximately 5-15% of women depending on definition.
- Patients who have PCOS are at higher risk for having insulin resistance, and for developing type II diabetes mellitus and possible cardiovascular disease.
- Non-classic adrenal hyperplasia due to 21-hydroxylase deficiency affects between 1-8% of androgen excess women, and is one of the most common autosomal recessive disorders of man.
- Hirsutism, the presence of excessive terminal hair growth in a male pattern in women, is one of the most common clinical signs of androgen excess depending on ethnicity.
- Other signs of androgen excess include irregular ovulation or menstruation, infertility, oily skin, acne and scalp hair loss.